Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection.
Identifieur interne : 001360 ( Main/Exploration ); précédent : 001359; suivant : 001361Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection.
Auteurs : Heesik Yoon [États-Unis] ; Kevin L. Legge ; Sun-Sang J. Sung ; Thomas J. BracialeSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2007.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (génétique), Activation des lymphocytes (immunologie), Animaux, Cellules cultivées, Cellules dendritiques (anatomopathologie), Cellules dendritiques (immunologie), Cellules dendritiques (virologie), Cinétique, Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (immunologie), Lymphocytes T CD8+ (immunologie), Lymphocytes T CD8+ (transplantation), Lymphocytes T CD8+ (virologie), Maladies pulmonaires (anatomopathologie), Maladies pulmonaires (immunologie), Maladies pulmonaires (virologie), Mouvement cellulaire (génétique), Mouvement cellulaire (immunologie), Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (immunologie), Noeuds lymphatiques (métabolisme), Réplication virale (immunologie), Souris, Souris de lignée BALB C, Souris transgéniques, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (immunologie), Transfert adoptif.
- MESH :
- anatomopathologie : Cellules dendritiques, Infections à Orthomyxoviridae, Maladies pulmonaires, Noeuds lymphatiques.
- génétique : Activation des lymphocytes, Mouvement cellulaire.
- immunologie : Activation des lymphocytes, Cellules dendritiques, Infections à Orthomyxoviridae, Lymphocytes T CD8+, Maladies pulmonaires, Mouvement cellulaire, Noeuds lymphatiques, Réplication virale, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A.
- métabolisme : Noeuds lymphatiques.
- virologie : Cellules dendritiques, Lymphocytes T CD8+, Maladies pulmonaires.
- transplantation : Animaux, Cellules cultivées, Cinétique, Lymphocytes T CD8+, Souris, Souris de lignée BALB C, Souris transgéniques, Transfert adoptif.
English descriptors
- KwdEn :
- Adoptive Transfer, Animals, CD8-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (transplantation), CD8-Positive T-Lymphocytes (virology), Cell Movement (genetics), Cell Movement (immunology), Cells, Cultured, Dendritic Cells (immunology), Dendritic Cells (pathology), Dendritic Cells (virology), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H2N2 Subtype (immunology), Kinetics, Lung Diseases (immunology), Lung Diseases (pathology), Lung Diseases (virology), Lymph Nodes (immunology), Lymph Nodes (metabolism), Lymph Nodes (pathology), Lymphocyte Activation (genetics), Lymphocyte Activation (immunology), Mice, Mice, Inbred BALB C, Mice, Transgenic, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (pathology), Virus Replication (immunology).
- MESH :
- genetics : Cell Movement, Lymphocyte Activation.
- immunology : CD8-Positive T-Lymphocytes, Cell Movement, Dendritic Cells, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Lung Diseases, Lymph Nodes, Lymphocyte Activation, Orthomyxoviridae Infections, Virus Replication.
- metabolism : Lymph Nodes.
- pathology : Dendritic Cells, Lung Diseases, Lymph Nodes, Orthomyxoviridae Infections.
- transplantation : CD8-Positive T-Lymphocytes.
- virology : CD8-Positive T-Lymphocytes, Dendritic Cells, Lung Diseases.
- Adoptive Transfer, Animals, Cells, Cultured, Kinetics, Mice, Mice, Inbred BALB C, Mice, Transgenic.
Abstract
We have used a TCR-transgenic CD8+ T cell adoptive transfer model to examine the tempo of T cell activation and proliferation in the draining lymph nodes (DLN) in response to respiratory virus infection. The T cell response in the DLN differed for mice infected with different type A influenza strains with the onset of T cell activation/proliferation to the A/JAPAN virus infection preceding the A/PR8 response by 12-24 h. This difference in T cell activation/proliferation correlated with the tempo of accelerated respiratory DC (RDC) migration from the infected lungs to the DLN in response to influenza virus infection, with the migrant RDC responding to the A/JAPAN infection exhibiting a more rapid accumulation in the lymph nodes (i.e., peak migration for A/JAPAN at 18 h, A/PR8 at 24-36 h). Furthermore, in vivo administration of blocking anti-CD62L Ab at various time points before/after infection revealed that the virus-specific CD8+ T cells entered the DLN and activated in a sequential "conveyor belt"-like fashion. These results indicate that the tempo of CD8+ T cell activation/proliferation after viral infection is dependent on the tempo of RDC migration to the DLN and that T cell activation occurs in an ordered sequential fashion.
DOI: 10.4049/jimmunol.179.1.391
PubMed: 17579060
Affiliations:
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Le document en format XML
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Legge</name></author><author><name sortKey="Sung, Sun Sang J" sort="Sung, Sun Sang J" uniqKey="Sung S" first="Sun-Sang J" last="Sung">Sun-Sang J. Sung</name></author><author><name sortKey="Braciale, Thomas J" sort="Braciale, Thomas J" uniqKey="Braciale T" first="Thomas J" last="Braciale">Thomas J. Braciale</name></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="ISSN">0022-1767</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adoptive Transfer</term><term>Animals</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>CD8-Positive T-Lymphocytes (transplantation)</term><term>CD8-Positive T-Lymphocytes (virology)</term><term>Cell Movement (genetics)</term><term>Cell Movement (immunology)</term><term>Cells, Cultured</term><term>Dendritic Cells (immunology)</term><term>Dendritic Cells (pathology)</term><term>Dendritic Cells (virology)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Kinetics</term><term>Lung Diseases (immunology)</term><term>Lung Diseases (pathology)</term><term>Lung Diseases (virology)</term><term>Lymph Nodes (immunology)</term><term>Lymph Nodes (metabolism)</term><term>Lymph Nodes (pathology)</term><term>Lymphocyte Activation (genetics)</term><term>Lymphocyte Activation (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Transgenic</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (pathology)</term><term>Virus Replication (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (génétique)</term><term>Activation des lymphocytes (immunologie)</term><term>Animaux</term><term>Cellules cultivées</term><term>Cellules dendritiques (anatomopathologie)</term><term>Cellules dendritiques (immunologie)</term><term>Cellules dendritiques (virologie)</term><term>Cinétique</term><term>Infections à Orthomyxoviridae (anatomopathologie)</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Lymphocytes T CD8+ (transplantation)</term><term>Lymphocytes T CD8+ (virologie)</term><term>Maladies pulmonaires (anatomopathologie)</term><term>Maladies pulmonaires (immunologie)</term><term>Maladies pulmonaires (virologie)</term><term>Mouvement cellulaire (génétique)</term><term>Mouvement cellulaire (immunologie)</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Noeuds lymphatiques (immunologie)</term><term>Noeuds lymphatiques (métabolisme)</term><term>Réplication virale (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris transgéniques</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H2N2 du virus de la grippe A (immunologie)</term><term>Transfert adoptif</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules dendritiques</term><term>Infections à Orthomyxoviridae</term><term>Maladies pulmonaires</term><term>Noeuds lymphatiques</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Movement</term><term>Lymphocyte Activation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Activation des lymphocytes</term><term>Mouvement cellulaire</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term><term>Cellules dendritiques</term><term>Infections à Orthomyxoviridae</term><term>Lymphocytes T CD8+</term><term>Maladies pulmonaires</term><term>Mouvement cellulaire</term><term>Noeuds lymphatiques</term><term>Réplication virale</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Cell Movement</term><term>Dendritic Cells</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Lung Diseases</term><term>Lymph Nodes</term><term>Lymphocyte Activation</term><term>Orthomyxoviridae Infections</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Noeuds lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dendritic Cells</term><term>Lung Diseases</term><term>Lymph Nodes</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules dendritiques</term><term>Lymphocytes T CD8+</term><term>Maladies pulmonaires</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Dendritic Cells</term><term>Lung Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adoptive Transfer</term><term>Animals</term><term>Cells, Cultured</term><term>Kinetics</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Transgenic</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Cinétique</term><term>Lymphocytes T CD8+</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris transgéniques</term><term>Transfert adoptif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have used a TCR-transgenic CD8+ T cell adoptive transfer model to examine the tempo of T cell activation and proliferation in the draining lymph nodes (DLN) in response to respiratory virus infection. The T cell response in the DLN differed for mice infected with different type A influenza strains with the onset of T cell activation/proliferation to the A/JAPAN virus infection preceding the A/PR8 response by 12-24 h. This difference in T cell activation/proliferation correlated with the tempo of accelerated respiratory DC (RDC) migration from the infected lungs to the DLN in response to influenza virus infection, with the migrant RDC responding to the A/JAPAN infection exhibiting a more rapid accumulation in the lymph nodes (i.e., peak migration for A/JAPAN at 18 h, A/PR8 at 24-36 h). Furthermore, in vivo administration of blocking anti-CD62L Ab at various time points before/after infection revealed that the virus-specific CD8+ T cells entered the DLN and activated in a sequential "conveyor belt"-like fashion. These results indicate that the tempo of CD8+ T cell activation/proliferation after viral infection is dependent on the tempo of RDC migration to the DLN and that T cell activation occurs in an ordered sequential fashion.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Braciale, Thomas J" sort="Braciale, Thomas J" uniqKey="Braciale T" first="Thomas J" last="Braciale">Thomas J. Braciale</name><name sortKey="Legge, Kevin L" sort="Legge, Kevin L" uniqKey="Legge K" first="Kevin L" last="Legge">Kevin L. Legge</name><name sortKey="Sung, Sun Sang J" sort="Sung, Sun Sang J" uniqKey="Sung S" first="Sun-Sang J" last="Sung">Sun-Sang J. Sung</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Yoon, Heesik" sort="Yoon, Heesik" uniqKey="Yoon H" first="Heesik" last="Yoon">Heesik Yoon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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